What is PT-141?
PT-141 is a synthetic peptide analog of alpha-melanocyte–stimulating hormone (α-MSH). It is intended for laboratory investigation of melanocortin receptor interaction and associated intracellular signaling pathways in controlled research environments.Mechanism of Research Interest
PT-141 is examined in vitro and in non-clinical models for its interaction with melanocortin receptors, including MC3R and MC4R. Research may include evaluation of receptor-binding characteristics, signal transduction activity, and peptide stability under experimental conditions.Why Researchers Study PT-141
- To analyze melanocortin receptor-binding activity in laboratory assays
- To evaluate intracellular signaling responses in controlled experimental models
- To examine structural and biochemical characteristics under research conditions
Research Background
PT-141 (Bremelanotide) (PT-141) is a synthetic peptide analog of alpha-MSH and a metabolite of Melanotan II. PT-141 has been investigated in laboratory research for its selective interaction with melanocortin-4 receptor (MC4R) signaling pathways in preclinical experimental models.
Laboratory Research Areas
In published scientific literature, PT-141 has been explored in the following research contexts:
- MC4R binding selectivity and activation in receptor assays
- Melanocortin pathway signaling characterization in in vitro models
- Comparative analysis with other melanocortin receptor ligands
- Peptide metabolite stability and structural characterization
Product Specifications
- Molecular Weight: ~1025 Da
- Form: Lyophilized powder
- Storage: Store at -20°C, protect from light
- Brand: Alpha Peptides
- Purity: ≥98% (verified by HPLC)
Quality & Testing Transparency
Every batch of PT-141 supplied by Alpha Peptides is accompanied by third-party analytical testing documentation. Our Certificates of Analysis (COAs) verify compound identity via mass spectrometry and purity via HPLC analysis. View our published testing records on the Certificates of Analysis page.
Published Research References
The following peer-reviewed publications provide context for the scientific investigation of this compound. These references are provided for informational purposes only.
- Molinoff PB, Shadiack AM, Earle D, et al. (2003). “PT-141: a melanocortin agonist for the treatment of sexual dysfunction.” Annals of the New York Academy of Sciences, 994, 96-102. PMID: 12851303
- Shadiack AM, Sharma SD, Earle DC, et al. (2007). “Melanocortins in the treatment of male and female sexual dysfunction.” Current Topics in Medicinal Chemistry, 7(11), 1137-1144. PMID: 17584134
Related Research Compounds
Researchers investigating this compound may also be interested in the following related research peptides:
| Attributes | Value |
|---|---|
| Weight | |
| Dimensions | |
| Dosage |
10 MG |
| Brand |
Alpha Peptides |
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