The Best Fat Loss Peptides Comparison Guide: GLP, AOD, Cagrilintide, MOTS C, and More
Peptide research has advanced rapidly in the last few years, especially in the area of metabolic health and fat loss. Many peptides now target appetite, metabolism, energy regulation, glucose control, and fat oxidation. But each peptide works through a different pathway, which means not all fat loss peptides are equal. Some help reduce hunger, some enhance metabolism, and others improve cellular energy or fat breakdown.
This guide compares the most well known fat loss peptides in research today, explains how each one works, and highlights which models or goals they are best suited for.
The Top Fat Loss Peptides Covered in This Guide
This comparison includes the peptides most often studied in fat loss and metabolism research:
- Semaglutide (GLP 1)
- Tirzepatide (GLP 1 + GIP)
- Retatrutide (GLP 1 + GIP + Glucagon)
- Cagrilintide (Amylin analog)
- AOD 9604 (Fat metabolism fragment)
- MOTS C (Mitochondrial peptide)
- KPV (Anti inflammation peptide that influences gut environment)
Each one affects the body differently.
The goal of this guide is to make those differences easy to understand.
1. Semaglutide
Semaglutide is the most widely recognized peptide studied for appetite suppression and metabolic control.
Mechanism
- Activates GLP 1 receptors
- Slows digestion
- Enhances satiety
- Reduces cravings
Research Outcomes
- strong appetite reduction
- improved blood glucose control
- consistent fat loss through caloric reduction
Best Use Case in Research
- appetite suppression focused studies
- long term weight control models
2. Tirzepatide
Tirzepatide activates GLP 1 and GIP receptors simultaneously, giving it a dual hormone effect.
Mechanism
- GLP 1 reduces appetite and slows digestion
- GIP influences metabolic flexibility and energy usage
Research Outcomes
- faster and more powerful appetite reduction than semaglutide
- improved insulin sensitivity
- more efficient fat loss
Best Use Case
- research models needing high appetite suppression
- metabolic performance studies
3. Retatrutide (GLP 3 RT / Reta)
Retatrutide is the most powerful GLP family peptide currently known in metabolic research because it activates three pathways at once.
Mechanism
- GLP 1: appetite control and slower digestion
- GIP: improved insulin signaling
- Glucagon: increased fat oxidation and energy expenditure
Research Outcomes
- extremely strong appetite suppression
- direct fat oxidation and increased energy burn
- significant improvements in metabolic rate
Best Use Case
- comprehensive fat loss research
- studies involving metabolic disorders
- high demand energy and fat oxidation models
Reta is often referred to as the most complete fat loss peptide in research.
4. Cagrilintide
Cagrilintide is an amylin analog that works entirely differently than GLP peptides.
Mechanism
- activates amylin receptors
- reduces hunger signals
- limits portion sizes
- decreases cravings and food reward
Research Outcomes
- powerful appetite suppression
- reduced emotional and reward based eating
- synergy with GLP peptides
Best Use Case
- research involving binge eating
- appetite control models
- combination studies with semaglutide or tirzepatide
Cagrilintide is considered the best peptide for controlling food reward pathways.
5. AOD 9604
AOD 9604 is a fragment of the HGH molecule designed specifically to study fat metabolism.
Mechanism
- stimulates lipolysis
- inhibits lipogenesis
- targets fat metabolism without increasing blood sugar
Research Outcomes
- increased fat oxidation
- better mobilization of stored fat
- improved metabolism without appetite effects
Best Use Case
- research on stubborn fat
- studies involving localized fat metabolism
- combination studies with GH peptides or GLP peptides
AOD 9604 does not affect appetite.
It works directly on fat metabolism pathways.
6. MOTS C
MOTS C is a mitochondrial peptide that promotes metabolic flexibility and cellular energy usage.
Mechanism
- activates AMPK
- enhances fat oxidation
- improves glucose utilization
- boosts mitochondrial efficiency
Research Outcomes
- better fat metabolism
- improved energy output
- reduced fat storage over time
Best Use Case
- endurance research
- metabolic syndrome models
- energy optimization studies
MOTS C is one of the most promising peptides in longevity and metabolic research.
7. KPV
Although KPV is not directly a fat loss peptide, its anti inflammatory gut effects can support weight and metabolic research.
Mechanism
- reduces gut inflammation
- improves intestinal balance
- supports digestion efficiency
- influences metabolic regulation
Research Outcomes
- improved gut environment
- better nutrient absorption
- indirect support for metabolic models
Best Use Case
- gut based metabolic research
- inflammation and digestion models
- combination stacks involving appetite and fat metabolism
KPV is often added as a supportive peptide rather than a central fat loss agent.
Comparison Table: Best Fat Loss Peptides
| Peptide | Primary Mechanism | Appetite Suppression | Fat Oxidation | Metabolic Benefits | Best For |
|---|---|---|---|---|---|
| Semaglutide | GLP 1 activation | Very high | Low to moderate | High | General weight loss studies |
| Tirzepatide | GLP 1 + GIP | Extremely high | Moderate | Very high | Metabolic flexibility studies |
| Retatrutide | GLP 1 + GIP + Glucagon | Extremely high | Very high | Extremely high | Comprehensive fat loss research |
| Cagrilintide | Amylin receptor activation | Very high | Low | High | Appetite control and cravings |
| AOD 9604 | Fat metabolism activation | None | High | Moderate | Fat oxidation models |
| MOTS C | AMPK and mitochondrial activation | Low | High | Very high | Energy and metabolic studies |
| KPV | Anti inflammatory pathway | None | Low | Indirect | Gut related metabolic support |
Which Peptide Is Best for Appetite Suppression
Top performers
- Retatrutide
- Tirzepatide
- Cagrilintide
- Semaglutide
Retatrutide is currently the strongest appetite suppression peptide in research.
Which Peptide Is Best for Direct Fat Burning
Top performers
- Retatrutide
- AOD 9604
- MOTS C
These peptides impact fat oxidation more directly.
Which Peptide Is Best for Metabolic Health
Top performers
- Retatrutide
- MOTS C
- Tirzepatide
These peptides have strong influence on energy pathways and glucose control.
Best Combinations for Fat Loss Research
1. Cagrilintide + Semaglutide
Targets hunger from two different systems.
2. Cagrilintide + Tirzepatide
Dual plus amylin triple appetite control.
3. Retatrutide + MOTS C
Fat oxidation pathway plus mitochondrial activation.
4. AOD 9604 + CJC 1295 or Ipamorelin
Fat metabolism support plus GH related recovery.
5. MOTS C + AOD 9604
Energy expenditure plus direct fat mobilization.
Final Summary: The Best Fat Loss Peptides
Strongest appetite suppression
- Retatrutide
- Tirzepatide
- Cagrilintide
Strongest fat oxidation
- Retatrutide
- AOD 9604
- MOTS C
Most complete fat loss peptide overall
- Retatrutide
Best supporting peptide
- KPV
Best for cravings
- Cagrilintide
Best overall metabolic enhancer
- MOTS C